Quattrocento

Leonardo da Vinci's "Mona Lisa" is a portrait of noblewoman Lisa Gherardini, wife of del Giocondo. Leonardo painted it and never parted with it, even when he moved to France. At his death it was acquired by King Francois Ier. The painting is particularly famous for the subject’s enigmatic expression, due in particular to the soft transition between colors technique (aka sfumato) used around the lips and the eyes.

School of da Vinci - Nude woman

Leonardo da Vinci - Vitruvian man

Andrea del Sarto's painting Leda and the swan shows the two protagonist in a tender embrace with their children playing at their feet.

Piero di Cosimo's "Portrait of Simonetta Vespucci" was executed after her death when 23. Simonetta is depicted as a bare-breasted, pure, young woman with a married-woman’s hairdo.

Domenico Ghirlandaio’s "Birth of Mary" is a large fresco in the Tornabuoni Chapel of Santa Maria Novella in Florence, painted around 1485–1490. It shows the moment aafter Anne has given birth to Mary, set not in biblical Palestine but in what looks like an elegant late-15th-century Florentine bedroom. Anne, the mother of Mary, reclines in a grand wooden bed, propped up against rich blue textiles, while attendants bustle around her.

Giovanni Bellini - Saint Francis in Ecstasy

Sandro Botticelli's "Spring (Primavera)" depicts figures from classical mythology in an orange grove with hundreds of plant and flower species.

Antonello da Messina - Portrait of a Man

Piero della Francesca - Diptych of Federico da Montefeltro and Battista Sforza

Antonello da Messina - Saint Jerome in his Study

Paolo Uccello - Saint George and the Dragon

Andrea Mantegna - The Crucifixion (bottom centak panel of the San Zeno altarpiece)

Filippo Lippi - Adoration in the forest

Andrea Mantegna - The Agony in the garden (bottom left panel of the San Zeno altarpiece)

Paolo Uccello's "The Battle of San Romano" is also called "Niccolò Mauruzi da Tolentino unseats Bernardino della Ciarda". It was part of a series of three paintings. The Battle of San Romano" depicts the decisive moment of the battle where the Sienese commander, Bernardino della Carda, in the middle of the painting, is thrown off his white horse by the black spear of a Florentine horseman riding the brown horse with red colors.

Stefano di Giovanni (aka Sassetta) - The Blessed Ranieri Frees the Poor from a Prison in Florence

Fra Angelico - Annunciation

Masolino da Panicale's "The Temptation of Adam and Eve" shows the famous scene from the Old Testament when the serpent from the book of Genesis tries to tempt Adam and Eve into breaking the rules that God had set for them.

Masaccio's "Expulsion from the Garden of Eden" depicts Adam and Eve being sent out of Paradise on Earth. The fresco is recognized as a landmark of Renaissance painting.

Masaccio - Virgin Mary in Majesty from San Giovenale Triptych (Maestà)